2024 Mixed effect model autocorrelation

A comparison to mixed models. We noted previously that there were ties between generalized additive and mixed models. Aside from the identical matrix representation noted in the technical section, one of the key ideas is that the penalty parameter for the smooth coefficients reflects the ratio of the residual variance to the variance components for the random effects (see Fahrmeier et al ... . Myslice papa murphy

Subject. Re: st: mixed effect model and autocorrelation. Date. Sat, 13 Oct 2007 12:00:33 +0200. Panel commands in Stata (note: only "S" capitalized!) usually accept unbalanced panels as input. -glamm- (remember the dashes!), which you can download from ssc (by typing: -ssc install gllamm-), allow for the option cluster, which at least partially ...To do this, you would specify: m2 <- lmer (Obs ~ Day + Treatment + Day:Treatment + (Day | Subject), mydata) In this model: The intercept if the predicted score for the treatment reference category at Day=0. The coefficient for Day is the predicted change over time for each 1-unit increase in days for the treatment reference category.6 Linear mixed-effects models with one random factor. 6.1 Learning objectives; 6.2 When, and why, would you want to replace conventional analyses with linear mixed-effects modeling? 6.3 Example: Independent-samples $t$-test on multi-level data. 6.3.1 When is a random-intercepts model appropriate? we use corCAR1, which implements a continuous-time first-order autocorrelation model (i.e. autocorrelation declines exponentially with time), because we have missing values in the data. The more standard discrete-time autocorrelation models (lme offers corAR1 for a first-order model and corARMA for a more general model) don’t work with ...At this point, it is important to highlight how spatial data is internally stored in a SpatialGridDataFrame and the latent effects described in Table 7.1. For some models, INLA considers data sorted by column, i.e., a vector with the first column of the grid from top to bottom, followed by the second column and so on.An individual-tree diameter growth model was developed for Cunninghamia lanceolata in Fujian province, southeast China. Data were obtained from 72 plantation-grown China-fir trees in 24 single-species plots. Ordinary non-linear least squares regression was used to choose the best base model from among 5 theoretical growth equations; selection criteria were the smallest absolute mean residual ...3.1 The nlme package. nlme is a package for fitting and comparing linear and nonlinear mixed effects models. It let’s you specify variance-covariance structures for the residuals and is well suited for repeated measure or longitudinal designs.Growth curve models (possibly Latent GCM) Mixed effects models. 이 모두는 mixed model 의 다른 종류를 말한다. 어떤 용어들은 역사가 깊고, 어떤 것들은 특수 분야에서 자주 사용되고, 어떤 것들은 특정 데이터 구조를 뜻하고, 어떤 것들은 특수한 케이스들이다. Mixed effects 혹은 mixed ...The PBmodcomp function can only be used to compare models of the same type and thus could not be used to test an LME model (Model IV) versus a linear model (Model V), an autocorrelation model (Model VIII) versus a linear model (Model V), or a mixed effects autocorrelation model (Models VI-VII) versus an autocorrelation model (Model VIII).What is autocorrelation? Generalized Additive Mixed Effects Models have several components: Smooth terms for covariates; Random Effects: Intercepts, Slopes and Smooths. Categorical Predictors; Interactions of (1)-(3) We can add one more component for autocorrelation: modeling the residuals: Covariance structure for the residuals. In R, the lme linear mixed-effects regression command in the nlme R package allows the user to fit a regression model in which the outcome and the expected errors are spatially autocorrelated. There are several different forms that the spatial autocorrelation can take and the most appropriate form for a given dataset can be assessed by looking ...The advantage of mixed effects models is that you can also account for non-independence among "slopes". As you said, you may assume more similarity from fish within tanks, but - e.g. - over time ... Feb 3, 2021 · I have temporal blocks in my data frame, so I took the effect of time dependency through a random intercept in a glmer model. Now I want to test the spatial autocorrelation in the residuals but I’m not sure if the test procedure based on the residual is the same as for the fixed-effect models since now I have time dependency. Jan 7, 2016 · Linear mixed-effect model without repeated measurements. The OLS model indicated that additional modeling components are necessary to account for individual-level clustering and residual autocorrelation. Linear mixed-effect models allow for non-independence and clustering by describing both between and within individual differences. Ultimately I'd like to include spatial autocorrelation with corSpatial(form = ~ lat + long) in the GAMM model, or s(lat,long) in the GAM model, but even in basic form I can't get the model to run. If it helps understand the structure of the data, I've added dummy code below (with 200,000 rows):Mixed-effects models allow multiple levels of variability; AKA hierarchical models, multilevel models, multistratum models; Good references on mixed-effects models: Bolker [1–3] Gelman & Hill [4] Pinheiro & Bates [5].However, in the nlme R code, both methods inhabit the ‘correlation = CorStruc’ code which can only be used once in a model. Therefore, it appears that either only spatial autocorrelation or only temporal autocorrelation can be addressed, but not both (see example code below).Gamma mixed effects models using the Gamma() or Gamma.fam() family object. Linear mixed effects models with right and left censored data using the censored.normal() family object. Users may also specify their own log-density function for the repeated measurements response variable, and the internal algorithms will take care of the optimization.In the present article, we suggested an extension of the mixed-effects location scale model that allows a researcher to include random effects for the means, the within-person residual variance, and the autocorrelation.The following simulates and fits a model where the linear predictor in the logistic regression follows a zero-mean AR(1) process, see the glmmTMB package vignette for more details.of freedom obtained by the same method used in the most recently ﬁt mixed model. If option dfmethod() is not speciﬁed in the previous mixed command, option small is not allowed. For certain methods, the degrees of freedom for some linear combinations may not be available. See Small-sample inference for ﬁxed effects in[ME] mixed for more ...The nlme package allows you to fit mixed effects models. So does lme4 - which is in some ways faster and more modern, but does NOT model heteroskedasticity or (!spoiler alert!) autocorrelation. Let’s try a model that looks just like our best model above, but rather than have a unique Time slope A comparison to mixed models. We noted previously that there were ties between generalized additive and mixed models. Aside from the identical matrix representation noted in the technical section, one of the key ideas is that the penalty parameter for the smooth coefficients reflects the ratio of the residual variance to the variance components for the random effects (see Fahrmeier et al ...1 Answer. Mixed models are often a good choice when you have repeated measures, such as here, within whales. lme from the nlme package can fit mixed models and also handle autocorrelation based on a AR (1) process, where values of X X at t − 1 t − 1 determine the values of X X at t t.Sep 16, 2018 · Recently I have made good use of Matlab's built-in functions for making linear mixed effects. Currently I am trying to model time-series data (neuronal activity) from cognitive experiments with the fitlme() function using two continuous fixed effects (linear speed and acceleration) and several, hierarchically nested categorical random factors (subject identity, experimental session and binned ... in nlme, it is possible to specify the variance-covariance matrix for the random effects (e.g. an AR (1)); it is not possible in lme4. Now, lme4 can easily handle very huge number of random effects (hence, number of individuals in a given study) thanks to its C part and the use of sparse matrices. The nlme package has somewhat been superseded ...This example will use a mixed effects model to describe the repeated measures analysis, using the lme function in the nlme package. Student is treated as a random variable in the model. The autocorrelation structure is described with the correlation statement. Recently I have made good use of Matlab's built-in functions for making linear mixed effects. Currently I am trying to model time-series data (neuronal activity) from cognitive experiments with the fitlme() function using two continuous fixed effects (linear speed and acceleration) and several, hierarchically nested categorical random factors (subject identity, experimental session and binned ...Linear mixed models allow for modeling fixed, random and repeated effects in analysis of variance models. “Factor effects are either fixed or random depending on how levels of factors that appear in the study are selected. An effect is called fixed if the levels in the study represent all possible levels of theTo do this, you would specify: m2 <- lmer (Obs ~ Day + Treatment + Day:Treatment + (Day | Subject), mydata) In this model: The intercept if the predicted score for the treatment reference category at Day=0. The coefficient for Day is the predicted change over time for each 1-unit increase in days for the treatment reference category.lmer (lme4) glmmTMB (glmmTMB) We will start by fitting the linear mixed effects model. data.hier.lme <- lme(y ~ x, random = ~1 | block, data.hier, method = "REML") The hierarchical random effects structure is defined by the random= parameter. In this case, random=~1|block indicates that blocks are random effects and that the intercept should be ...Mixed-effects models allow multiple levels of variability; AKA hierarchical models, multilevel models, multistratum models; Good references on mixed-effects models: Bolker [1–3] Gelman & Hill [4] Pinheiro & Bates [5]. Mixed-effects models allow multiple levels of variability; AKA hierarchical models, multilevel models, multistratum models; Good references on mixed-effects models: Bolker [1–3] Gelman & Hill [4] Pinheiro & Bates [5].c (Claudia Czado, TU Munich) – 11 – Likelihood Inference for LMM: 1) Estimation of β and γ for known G and R Estimation of β: Using (5), we have as MLE or weighted LSE of βYour second model is a random-slopes model; it allows for random variation in the individual-level slopes (and in the intercept, and a correlation between slopes and intercepts) m2 <- update(m1, random = ~ minutes|ID) I'd suggest the random-slopes model is more appropriate (see e.g. Schielzeth and Forstmeier 2009). Some other considerations:May 5, 2022 · The PBmodcomp function can only be used to compare models of the same type and thus could not be used to test an LME model (Model IV) versus a linear model (Model V), an autocorrelation model (Model VIII) versus a linear model (Model V), or a mixed effects autocorrelation model (Models VI-VII) versus an autocorrelation model (Model VIII). A random effects model that contains only random intercepts, which is the most common use of mixed effect modeling in randomized trials, assumes that the responses within subject are exchangeable. This can be seen from the statement of the linear mixed effects model with random intercepts.The “random effects model” (also known as the mixed effects model) is used when the analysis must account for both fixed and random effects in the model. This occurs when data for a subject are independent observations following a linear model or GLM, but the regression coefficients vary from person to person. Infant growth is a3.1 The nlme package. nlme is a package for fitting and comparing linear and nonlinear mixed effects models. It let’s you specify variance-covariance structures for the residuals and is well suited for repeated measure or longitudinal designs.See full list on link.springer.com The model that I have arrived at is a zero-inflated generalized linear mixed-effects model (ZIGLMM). Several packages that I have attempted to use to fit such a model include glmmTMB and glmmADMB in R. My question is: is it possible to account for spatial autocorrelation using such a model and if so, how can it be done?Gamma mixed effects models using the Gamma() or Gamma.fam() family object. Linear mixed effects models with right and left censored data using the censored.normal() family object. Users may also specify their own log-density function for the repeated measurements response variable, and the internal algorithms will take care of the optimization.The “random effects model” (also known as the mixed effects model) is used when the analysis must account for both fixed and random effects in the model. This occurs when data for a subject are independent observations following a linear model or GLM, but the regression coefficients vary from person to person. Infant growth is aModels all contained the same fixed effects, were compared using AIC, and were fitted by REML (to allow comparison of different correlation structures by AIC). I'm using the R package nlme and the gls function. Question 1. The GLS models' residuals still display almost identical cyclical patterns when plotted against time.1 Answer. Mixed models are often a good choice when you have repeated measures, such as here, within whales. lme from the nlme package can fit mixed models and also handle autocorrelation based on a AR (1) process, where values of X X at t − 1 t − 1 determine the values of X X at t t.Growth curve models (possibly Latent GCM) Mixed effects models. 이 모두는 mixed model 의 다른 종류를 말한다. 어떤 용어들은 역사가 깊고, 어떤 것들은 특수 분야에서 자주 사용되고, 어떤 것들은 특정 데이터 구조를 뜻하고, 어떤 것들은 특수한 케이스들이다. Mixed effects 혹은 mixed ... Jul 1, 2021 · Mixed Effects Models - Autocorrelation. Jul. 1, 2021 • 0 likes • 171 views. Download Now. Download to read offline. Education. Lecture 19 from my mixed-effects modeling course: Autocorrelation in longitudinal and time-series data. Scott Fraundorf Follow. I am seeking advice on how to effectively eliminate autocorrelation from a linear mixed model. My experimental design and explanation of fixed and random factors can be found here from an earlier question I asked: Crossed fixed effects model specification including nesting and repeated measures using glmm in RThe model that I have arrived at is a zero-inflated generalized linear mixed-effects model (ZIGLMM). Several packages that I have attempted to use to fit such a model include glmmTMB and glmmADMB in R. My question is: is it possible to account for spatial autocorrelation using such a model and if so, how can it be done?Jul 7, 2020 · 1 Answer. Mixed models are often a good choice when you have repeated measures, such as here, within whales. lme from the nlme package can fit mixed models and also handle autocorrelation based on a AR (1) process, where values of X X at t − 1 t − 1 determine the values of X X at t t. Feb 3, 2021 · I have temporal blocks in my data frame, so I took the effect of time dependency through a random intercept in a glmer model. Now I want to test the spatial autocorrelation in the residuals but I’m not sure if the test procedure based on the residual is the same as for the fixed-effect models since now I have time dependency. Oct 11, 2022 · The code below shows how the random effects (intercepts) of mixed models without autocorrelation terms can be extracted and plotted. However, this approach does not work when modelling autocorrelation in glmmTMB. Use reproducible example data from this question: glmmTMB with autocorrelation of irregular times we use corCAR1, which implements a continuous-time first-order autocorrelation model (i.e. autocorrelation declines exponentially with time), because we have missing values in the data. The more standard discrete-time autocorrelation models (lme offers corAR1 for a first-order model and corARMA for a more general model) don’t work with ...Linear Mixed Effects Models. Linear Mixed Effects models are used for regression analyses involving dependent data. Such data arise when working with longitudinal and other study designs in which multiple observations are made on each subject. Some specific linear mixed effects models are. Random intercepts models, where all responses in a ... Linear mixed models allow for modeling fixed, random and repeated effects in analysis of variance models. “Factor effects are either fixed or random depending on how levels of factors that appear in the study are selected. An effect is called fixed if the levels in the study represent all possible levels of theSep 22, 2015 · $\begingroup$ it's more a please check that I have taken care of the random effects, autocorrelation, and a variance that increases with the mean properly. $\endgroup$ – M.T.West Sep 22, 2015 at 12:15 This is what we refer to as “random factors” and so we arrive at mixed effects models. Ta-daa! 6. Mixed effects models. A mixed model is a good choice here: it will allow us to use all the data we have (higher sample size) and account for the correlations between data coming from the sites and mountain ranges. a combination of both models (ARMA). random effects that model independence among observations from the same site using GAMMs. That is, in addition to changing the basis as with the nottem example, we can also add complexity to the model by incorporating an autocorrelation structure or mixed effects using the gamm() function in the mgcv packageRandom intercept + Autocorrelation structure on the errors, and; Autocorrelation structure on the errors only (using gls() command). I fit model 3 because I've been taught that sometimes an autocorrelation structure is enough for longitudinal data. For model 1, variance of random effect (intercept) was 676.9 (and accounted for 62% of total ...In the present article, we suggested an extension of the mixed-effects location scale model that allows a researcher to include random effects for the means, the within-person residual variance, and the autocorrelation.Therefore, even greater sampling rates will be required when autocorrelation is present to meet the levels prescribed by analyses of the power and precision when estimating individual variation using mixed effect models (e.g., Wolak et al. 2012; Dingemanse and Dochtermann 2013)Models all contained the same fixed effects, were compared using AIC, and were fitted by REML (to allow comparison of different correlation structures by AIC). I'm using the R package nlme and the gls function. Question 1. The GLS models' residuals still display almost identical cyclical patterns when plotted against time.PROC MIXED in the SAS System provides a very flexible modeling environment for handling a variety of repeated measures problems. Random effects can be used to build hierarchical models correlating measurements made on the same level of a random factor, including subject-specific regression models, while a variety of covariance and What is autocorrelation? Generalized Additive Mixed Effects Models have several components: Smooth terms for covariates; Random Effects: Intercepts, Slopes and Smooths. Categorical Predictors; Interactions of (1)-(3) We can add one more component for autocorrelation: modeling the residuals: Covariance structure for the residuals. in nlme, it is possible to specify the variance-covariance matrix for the random effects (e.g. an AR (1)); it is not possible in lme4. Now, lme4 can easily handle very huge number of random effects (hence, number of individuals in a given study) thanks to its C part and the use of sparse matrices. The nlme package has somewhat been superseded ...The first model was a longitudinal mixed-effect model with a first-order autocorrelation structure, and the second model was the E-MELS. Both were implemented as described above. The third model was a longitudinal mixed-effect model with a Lasso penalty. in nlme, it is possible to specify the variance-covariance matrix for the random effects (e.g. an AR (1)); it is not possible in lme4. Now, lme4 can easily handle very huge number of random effects (hence, number of individuals in a given study) thanks to its C part and the use of sparse matrices. The nlme package has somewhat been superseded ...Recently I have made good use of Matlab's built-in functions for making linear mixed effects. Currently I am trying to model time-series data (neuronal activity) from cognitive experiments with the fitlme() function using two continuous fixed effects (linear speed and acceleration) and several, hierarchically nested categorical random factors (subject identity, experimental session and binned ...This example will use a mixed effects model to describe the repeated measures analysis, using the lme function in the nlme package. Student is treated as a random variable in the model. The autocorrelation structure is described with the correlation statement.Yes. How can glmmTMB tell how far apart moments in time are if the time sequence must be provided as a factor? The assumption is that successive levels of the factor are one time step apart (the ar1 () covariance structure does not allow for unevenly spaced time steps: for that you need the ou () covariance structure, for which you need to use ...May 22, 2018 · 10.8k 7 39 67. 1. All LMMs correspond to a multivariate normal model (while the converse is not true) with a structured variance covariance matrix, so "all" you have to do is to work out the marginal variance covariance matrix for the nested random-effect model and fit that - whether gls is then able to parameterize that model is then the next ... I am seeking advice on how to effectively eliminate autocorrelation from a linear mixed model. My experimental design and explanation of fixed and random factors can be found here from an earlier question I asked: Crossed fixed effects model specification including nesting and repeated measures using glmm in REight models were estimated in which subjects nervousness values were regressed on all aforementioned predictors. The first model was a standard mixed-effects model with random effects for the intercept and the slope but no autocorrelation (Model 1 in Tables 2 and 3). The second model included such an autocorrelation (Model 2). Jul 1, 2021 · Mixed Effects Models - Autocorrelation. Jul. 1, 2021 • 0 likes • 171 views. Download Now. Download to read offline. Education. Lecture 19 from my mixed-effects modeling course: Autocorrelation in longitudinal and time-series data. Scott Fraundorf Follow. Here's a mixed model without autocorrelation included: cmod_lme <- lme(GS.NEE ~ cYear, data=mc2, method="REML", random = ~ 1 + cYear | Site) and you can explore the autocorrelation by using plot(ACF(cmod_lme)) .1 discussing the implicit correlation structure that is imposed by a particular model. This is easiest seen in repeated measures. The simplest model with occasions nested in individuals with a ...Subject. Re: st: mixed effect model and autocorrelation. Date. Sat, 13 Oct 2007 12:00:33 +0200. Panel commands in Stata (note: only "S" capitalized!) usually accept unbalanced panels as input. -glamm- (remember the dashes!), which you can download from ssc (by typing: -ssc install gllamm-), allow for the option cluster, which at least partially ... Linear Mixed Effects Models. Linear Mixed Effects models are used for regression analyses involving dependent data. Such data arise when working with longitudinal and other study designs in which multiple observations are made on each subject. Some specific linear mixed effects models are. Random intercepts models, where all responses in a ...See full list on link.springer.com Nov 1, 2019 · Therefore, even greater sampling rates will be required when autocorrelation is present to meet the levels prescribed by analyses of the power and precision when estimating individual variation using mixed effect models (e.g., Wolak et al. 2012; Dingemanse and Dochtermann 2013) GLM, generalized linear model; RIS, random intercepts and slopes; LME, linear mixed-effects model; CAR, conditional autoregressive priors. To reduce the number of explanatory variables in the most computationally demanding of the analyses accounting for spatial autocorrelation, an initial Bayesian CAR analysis was conducted using the CARBayes ...In R, the lme linear mixed-effects regression command in the nlme R package allows the user to fit a regression model in which the outcome and the expected errors are spatially autocorrelated. There are several different forms that the spatial autocorrelation can take and the most appropriate form for a given dataset can be assessed by looking ... the mixed-effect model with a ﬁrst-order autocorrelation structure. The model was estimated using the R package nlme and the lme function (Pinheiro et al., 2020 ).Is it accurate to say that we used a linear mixed model to account for missing data (i.e. non-response; technology issues) and participant-level effects (i.e. how frequently each participant used ...Jul 25, 2020 · How is it possible that the model fits perfectly the data while the fixed effect is far from overfitting ? Is it normal that including the temporal autocorrelation process gives such R² and almost a perfect fit ? (largely due to the random part, fixed part often explains a small part of the variance in my data). Is the model still interpretable ?

I used this data to run 240 basic linear models of mean Length vs mean Temperature, the models were ran per location box, per month, per sex. I am now looking to extend my analysis by using a mixed effects model, which attempts to account for the temporal (months) and spatial (location boxes) autocorrelation in the dataset.. Rent a center online shopping

This example will use a mixed effects model to describe the repeated measures analysis, using the lme function in the nlme package. Student is treated as a random variable in the model. The autocorrelation structure is described with the correlation statement.Chapter 10 Mixed Effects Models. Chapter 10. Mixed Effects Models. The assumption of independent observations is often not supported and dependent data arises in a wide variety of situations. The dependency structure could be very simple such as rabbits within a litter being correlated and the litters being independent.At this point, it is important to highlight how spatial data is internally stored in a SpatialGridDataFrame and the latent effects described in Table 7.1. For some models, INLA considers data sorted by column, i.e., a vector with the first column of the grid from top to bottom, followed by the second column and so on.Chapter 10 Mixed Effects Models. Chapter 10. Mixed Effects Models. The assumption of independent observations is often not supported and dependent data arises in a wide variety of situations. The dependency structure could be very simple such as rabbits within a litter being correlated and the litters being independent.Sep 16, 2018 · Recently I have made good use of Matlab's built-in functions for making linear mixed effects. Currently I am trying to model time-series data (neuronal activity) from cognitive experiments with the fitlme() function using two continuous fixed effects (linear speed and acceleration) and several, hierarchically nested categorical random factors (subject identity, experimental session and binned ... Growth curve models (possibly Latent GCM) Mixed effects models. 이 모두는 mixed model 의 다른 종류를 말한다. 어떤 용어들은 역사가 깊고, 어떤 것들은 특수 분야에서 자주 사용되고, 어떤 것들은 특정 데이터 구조를 뜻하고, 어떤 것들은 특수한 케이스들이다. Mixed effects 혹은 mixed ...The “random effects model” (also known as the mixed effects model) is used when the analysis must account for both fixed and random effects in the model. This occurs when data for a subject are independent observations following a linear model or GLM, but the regression coefficients vary from person to person. Infant growth is aThis example will use a mixed effects model to describe the repeated measures analysis, using the lme function in the nlme package. Student is treated as a random variable in the model. The autocorrelation structure is described with the correlation statement.Gamma mixed effects models using the Gamma() or Gamma.fam() family object. Linear mixed effects models with right and left censored data using the censored.normal() family object. Users may also specify their own log-density function for the repeated measurements response variable, and the internal algorithms will take care of the optimization. Aug 8, 2018 · 3. MIXED EFFECTS MODELS 3.1 Overview of mixed effects models When a regression contains both random and fixed effects, it is said to be a mixed effects model, or simply, a mixed model. Fixed effects are those with which most researchers are familiar. Any covariate that is assumed to have the same effect for all responses throughout the Mar 29, 2021 · Ultimately I'd like to include spatial autocorrelation with corSpatial(form = ~ lat + long) in the GAMM model, or s(lat,long) in the GAM model, but even in basic form I can't get the model to run. If it helps understand the structure of the data, I've added dummy code below (with 200,000 rows): the mixed-effect model with a ﬁrst-order autocorrelation structure. The model was estimated using the R package nlme and the lme function (Pinheiro et al., 2020 ).Aug 9, 2023 · Arguments. the value of the lag 1 autocorrelation, which must be between -1 and 1. Defaults to 0 (no autocorrelation). a one sided formula of the form ~ t, or ~ t | g, specifying a time covariate t and, optionally, a grouping factor g. A covariate for this correlation structure must be integer valued. When a grouping factor is present in form ... You should try many of them and keep the best model. In this case the spatial autocorrelation in considered as continous and could be approximated by a global function. Second, you could go with the package mgcv, and add a bivariate spline (spatial coordinates) to your model. This way, you could capture a spatial pattern and even map it.I used this data to run 240 basic linear models of mean Length vs mean Temperature, the models were ran per location box, per month, per sex. I am now looking to extend my analysis by using a mixed effects model, which attempts to account for the temporal (months) and spatial (location boxes) autocorrelation in the dataset.$\begingroup$ it's more a please check that I have taken care of the random effects, autocorrelation, and a variance that increases with the mean properly. $\endgroup$ – M.T.West Sep 22, 2015 at 12:15.

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